Prescribing Safety Assessment (PSA) Practice Exam

What side effects are most commonly linked to Phenytoin?

1. Rash, teratogenicity

2. Ataxia, peripheral neuropathy

3. Fatigue, mood disorders

4. Weight gain

The correct answer is: Ataxia, peripheral neuropathy

Phenytoin is an antiepileptic medication primarily used to manage and prevent seizures. Among its various side effects, ataxia and peripheral neuropathy are notably prominent. Ataxia, which refers to a lack of voluntary muscle coordination, can occur due to phenytoin's impact on the central nervous system. Peripheral neuropathy, characterized by weakness, numbness, or pain in the extremities, is another well-documented consequence of long-term phenytoin therapy. The association between these side effects and phenytoin is particularly significant for healthcare professionals monitoring patients on this medication. Recognizing these potential adverse effects is crucial for timely intervention and management to enhance patient safety and treatment efficacy.