Prescribing Safety Assessment (PSA) Practice Exam

What is NOT a cause of thrombocytopenia?

1. Viral infection

2. Chronic kidney disease

3. Myeloproliferative disorders

4. Penicillamine use

The correct answer is: Myeloproliferative disorders

Thrombocytopenia, defined as a low platelet count, can arise from various underlying conditions and factors. In the context of this question, myeloproliferative disorders generally refer to a group of diseases characterized by the excessive production of blood cells, including platelets, which can actually lead to thrombocytosis rather than thrombocytopenia. Viral infections can cause thrombocytopenia through mechanisms like bone marrow suppression or increased platelet destruction. Chronic kidney disease is also associated with low platelet counts due to uremic toxins affecting platelet function or production. Penicillamine, a medication used to treat conditions like rheumatoid arthritis and Wilson's disease, may lead to thrombocytopenia through hypersensitivity reactions or bone marrow suppression. Therefore, myeloproliferative disorders are not a direct cause of thrombocytopenia, as these conditions typically result in elevated platelet counts rather than a reduction. Understanding the relationship between different medical conditions and platelet levels is crucial in managing and diagnosing hematological issues.