Prescribing Safety Assessment (PSA) Practice Exam

What is a significant side effect of Sodium Valproate related to weight?

1. Weight loss

2. Weight gain

3. No impact on weight

4. Sudden weight changes

The correct answer is: Weight gain

Sodium Valproate is known to be associated with significant weight gain in patients. This side effect can be particularly concerning, as it may affect compliance with the medication and overall patient health. The weight gain attributed to Sodium Valproate is thought to be due to various factors, including alterations in metabolism, appetite stimulation, and changes in energy balance that can occur with the medication's use. While some medications may cause weight loss or have minimal impact on weight, Sodium Valproate’s association with weight gain is well-documented and recognized in clinical practice. Sudden weight changes—while they can be relevant for various medical conditions or other drug side effects—do not specifically capture the ongoing issue of sustained weight gain associated with Sodium Valproate. Understanding this side effect is important for monitoring patients and discussing potential lifestyle considerations or adjustments that may be needed during treatment.