Prescribing Safety Assessment (PSA) Practice Exam

What is a significant side effect of Clozapine?

1. Weight gain

2. Gastrointestinal disturbance

3. Agranulocytosis

4. Drowsiness

The correct answer is: Agranulocytosis

Clozapine is an atypical antipsychotic that is primarily used in treatment-resistant schizophrenia. One of the most significant and serious side effects associated with its use is agranulocytosis, which is a potentially life-threatening condition characterized by a dangerously low level of neutrophils, a type of white blood cell essential for fighting off infections. This risk necessitates regular monitoring of blood counts in patients receiving clozapine therapy to detect any decrease in neutrophil levels early and to manage the situation promptly to prevent severe infections and other complications. In addition to agranulocytosis, clozapine may also cause other side effects, such as weight gain, sedation, and gastrointestinal disturbances, but these are generally considered less acute and serious compared to the risk of agranulocytosis. Monitoring protocols, including mandatory blood tests, are established to mitigate this risk and ensure patient safety during treatment with clozapine.