Prescribing Safety Assessment (PSA) Practice Exam

What is a rare but serious side effect associated with Lamotrigine?

1. Gum hyperplasia

2. Fatigue

3. Stevens-Johnson syndrome

4. Teratogenicity

The correct answer is: Stevens-Johnson syndrome

Stevens-Johnson syndrome (SJS) is a rare but serious skin reaction that can occur as a side effect of lamotrigine. It is characterized by the sudden onset of a rash that can spread and cause the skin to blister and peel away, leading to potentially life-threatening complications. The risk of developing SJS is particularly heightened in the context of lamotrigine use, especially when the drug is increased too quickly or combined with other medications that also increase the risk of severe skin reactions. Recognizing the signs and symptoms of SJS, such as fever, flu-like symptoms, and a painful rash, is crucial for early intervention. This includes discontinuing lamotrigine immediately upon suspicion of this syndrome to prevent further progression and complications. While other side effects like gum hyperplasia, fatigue, and teratogenicity can be associated with different medications or conditions, the association of lamotrigine with Stevens-Johnson syndrome stands out due to its severity and the need for vigilant monitoring during treatment.