Prescribing Safety Assessment (PSA) Practice Exam

What is a common side effect of calcium channel blockers like Amlodipine?

1. Headache

2. Peripheral Oedema

3. Nausea

4. Dry mouth

The correct answer is: Peripheral Oedema

Peripheral oedema is a well-recognized side effect of calcium channel blockers such as Amlodipine. These medications work by blocking calcium from entering the cells of the heart and blood vessel walls, which relaxes the blood vessels and lowers blood pressure. However, this mechanism can also lead to an increase in fluid retention and the dilation of blood vessels in the lower extremities, ultimately causing peripheral oedema. While headaches, nausea, and dry mouth can occur with various medications, they are not specifically associated with calcium channel blockers to the same extent. Peripheral oedema is particularly prevalent in patients treated with Amlodipine, making it a key point for practitioners to consider when managing potential side effects. Recognizing this side effect is important for clinicians to provide appropriate patient counseling and management strategies if it occurs.