Prescribing Safety Assessment (PSA) Practice Exam

What are some common side effects of Levetiracetam?

1. Rash, rarely Stevens-Johnson syndrome

2. Fatigue, mood disorders and agitation

3. Ataxia, nystagmus

4. Tremor, weight gain

The correct answer is: Fatigue, mood disorders and agitation

The selection of fatigue, mood disorders, and agitation as common side effects of Levetiracetam is accurate and reflects the established profile of this medication. Levetiracetam, an antiepileptic drug, is known to have neuropsychiatric side effects, which can significantly impact a patient's quality of life. Fatigue is often reported as patients may experience drowsiness or a general lack of energy. Mood disorders, including depression and anxiety, are also crucial considerations since they can affect treatment adherence and overall mental health. Agitation is another side effect that can manifest in some patients, potentially leading to behavioral changes or increased anxiety levels. These effects stem from the way Levetiracetam interacts with neurotransmitter systems in the brain, particularly its influence on GABAergic and glutamatergic pathways. This action can lead to the central nervous system symptoms observed. Understanding this side effect profile is essential for clinicians to monitor and adjust treatment plans accordingly, as well as for providing adequate support to patients experiencing these challenges during therapy.